Department of Combinatorial Chemistry
Scientific research programme includes two central themes:
Design of fluorescent probes for the study on biopolymers.
Development of anticancer drugs based on computer simulation, combinatorial
chemistry and biological testing.
Ongoing research projects and accomplishments:
- The Group of Design of fluorescent dyes is engaged in the development of
novel fluorescent probes for application in diagnostics systems, elaboration of
new methods for oligonucleotides and proteins labelling by polymethine dyes. The
interaction mechanism of cyanic dyes with DNA, RNA and proteins is also being
studied.
- The Group of Chemistry of proteinkinase inhibitors is involved in an active
search for potential inhibitors of CK2 kinase as anticancer drugs, based on the
synthesis of combinatorial libraries of chemical compounds.
- The Group of Molecular Design is working at in silico design of
proteinkinase inhibitors.
- The Department coordinates the Ukrainian scientific network for anticancer
drugs, using modern techniques of computer simulation, combinatorial chemistry
and biological testing.
Selected publications:
- Wetzl B.K., Yarmoluk S.M., Craig D.B., and Wolfbeis O.S. Chameleon labels for Staining and quantifying proteins // Angew. Chem. Int. Ed. – 2004. – Vol.43. – P. 5400 5402.
- Yarmoluk S.M., Lukashov S.S., Ogul’chansky T.Y., Losytskyy M.Y., and Kornjushyna O.S. Interaction of cyanine dyes with nucleic acids. XXI. Arguments for haft-intercalation model of interaction // Biopolymers. – 2001. – Vol. 62, ¹ 4. – P. 219–227.
- Ogul’chansky T.Yu., Losytskyy M.Y., Kovalska V.B., Yashchuk V.M., Yarmoluk S.M. Interaction of cyanine dyes with nucleic acids. XXIV. Aggregation of cyanine dyes in presence of DNA and its manifestation in absorption and fluorescence spectra // Spectrochimica Acta Part A. – 2001. – Vol. 57. – P. 1525–1527.
